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The SFP1 is a potential host gene for
yeast prion-like determinant [ISP+].
  • Sofia Rodionova, Tatiana Rogoza, Kirill Volkov, Ludmila Mironova



  • Department of Genetics, St. Petersburg University
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Prion diseases
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non-Mendelian genetic element [ISP+]
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non-Mendelian genetic element [ISP+]
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Insertion library
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Identification of SFP1 gene
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SFP1
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Deletion of SFP1
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SFP1 extra copy induces
appearance of [ISP+]
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"The SFP1 gene is necessary..."
  • The SFP1 gene is necessary for the [ISP+] propagation


  • The SFP1 overexpression induces antisuppression in [isp-] strain








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Our results allow us to propose
two opportunities:


  • 1) [ISP+] is a product of prion conversion of Sfp1 protein.


  • 2) Translation of [ISP+] host gene is under the tight control of Sfp1p.
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Acknowledgments:
  • Tatiana Rogoza
  • Olga Viktorovskaja
  • Kirill Osipov
  • Kirill Volkov
  • Ludmila Mironova
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